
Menopause is clinically defined as 12 consecutive months without a menstrual period. The average age in the United States is 51. The broader transition includes three stages: perimenopause (fluctuating hormones, irregular cycles), menopause (the 12-month milestone), and postmenopause (hormone levels stabilize at lower levels). About 5% of women experience early menopause (ages 40–45), and 1% experience premature menopause before 40.
Hot flashes affect over 70% of women during perimenopause. Other symptoms include:
Declining estrogen and progesterone drive most symptoms. As estrogen falls, metabolism, energy regulation, and fat storage all shift. Insulin resistance and cholesterol imbalances may become more common. Many women notice increased abdominal fat, loss of muscle mass, and disrupted sleep from night sweats that further compounds fatigue and mood changes.
Most cases are diagnosed clinically — based on age, symptoms, and 12 months without a period. Blood tests (FSH and estrogen) can help in cases where menstrual history is unclear (e.g., post-hysterectomy, endometrial ablation, or birth control use). Thyroid testing is also sometimes recommended, as thyroid disorders share overlapping symptoms and a similar age of onset in women.
Speak with your provider if you experience severe or disruptive symptoms, signs of early menopause, or unexplained weight loss, fatigue, or bleeding. Any vaginal bleeding after menopause must always be evaluated — it may indicate a serious underlying condition.
Source: Thorne Take 5 Daily — Sarah Daglis, ND, MS (April 20, 2026)
